High doses of amphetamines can cause serious cardiovascular events including stroke and myocardial infarction that may lead to deathĬhronic use of amphetamines at high doses results in drug dependence and tolerance. Increased blood pressure and heart rate, irregular heartbeat.Psychosis with paranoid delusions or hallucinations.Some of the more common short-term side effects of amphetamine abuse include: There are several short-term side effects of amphetamine abuse, some of which can be serious. Short-Term Side Effects Long-Term Effects Side Effects of Polysubstance Abuse Behavioral signs of amphetamine abuse include: In addition to physical signs, there are several behavioral signs of amphetamine abuse. Thus long-term use can result in physical addiction to amphetamines. Furthermore, larger amounts of amphetamines are required to produce the desired effects of the drug, resulting in drug tolerance developing. Long-term use can lead to the development of physical dependence on the drug with amphetamine intake necessary for the individual to function normally.
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